中国科学院大连化学物理研究所

简历介绍

徐兆超，博士，研究员，博士生导师。2001年和2006年在大连理工大学先后获得学士和博士学位，师从钱旭红院士，2006-2008年在韩国梨花女子大学做博士后，2008-2011年在英国剑桥大学做赫考尔.史密斯研究员，2011年加入大连化学物理研究所并成立“分子探针与荧光成像”研究组。

主要从事超分辨成像荧光染料分子科学和产品工程，及其在细胞器网络为典型代表的过程动态超分辨成像中的应用研究。围绕着过程动态超分辨成像亟需荧光分子开关的匀质闪烁和光稳定性等多种性能协同突破的关键科学问题，（1）原创性地发展了“分子内氢键调控的匀质闪烁荧光染料”，提出了“缓冲荧光探针”抵抗光漂白的策略，突破了目前20 nm空间分辨率的瓶颈和难以动态成像的难题，实现了在9 nm / 20 ms时空分辨率下连续超分辨成像40分钟。（2）将多色匀闪荧光染料用于细胞器网络动态成像，发现了多种未见报道的细胞器动态行为和作用方式。发现了新冠病毒壳蛋白入侵细胞的过程细节，筛选获得3个抗新冠抑制剂。（3）基于大量染料结构和发光性能的计算处理，发展了染料发光构效关系理论和功能染料高效开发方法，形成了超分辨成像荧光染料品牌产品DICP-Fluor和完备的荧光试剂产品线，可满足不同类型超分辨成像显微镜的需求。已发表论文130余篇，包括JACS（6篇）、Angew（9篇），被引用11000多次。近5年以第一发明人申请专利118项，已授权63项。受邀编写了《荧光染料及其生物医学应用》（2022年1月化学工业出版社）一书中的“超分辨成像荧光染料”章节。

获得国家基金委杰出青年基金、基金委优秀青年基金、基金委面上项目（4）等项目资助。2015-2021年连续入选爱思唯尔中国高被引学者榜单，获得2018年度国际Czarnik青年科学家奖，为该奖项首位中国获奖者。获得2018年度中国分析测试协会科学技术奖二等奖。获得2019年大连市人民政府特殊津贴。获得中国科技期刊卓越行动计划2021年度优秀审稿人奖。学术兼职包括：Coord. Chem. Rev.编委，Chin. Chem. Lett. 副主编，Acta Pharm. Sin. B 青年编委，Sci. Rep.编委，华东理工大学学报执行编委，中国分析测试协会青年学术委员会委员，中科院青年联合会第四届委员，辽宁省细胞生物学学会肿瘤细胞与分子生物学分会常务理事。

研究组主页：http://www.zcxu.dicp.ac.cn/

研究方向

职务

社会任职

获奖及荣誉

代表论著

1. Qinglong Qiao, Wenjuan Liu, Yinchan Zhang, Jie Chen, Guangying Wang, Yi Tao, Lu Miao, Wenchao Jiang, Kai An, Zhaochao Xu*, In Situ Real-time Nanoscale Resolution of Structural Evolution and Dynamics of Fluorescent Self-assemblies by Super-Resolution Imaging, Angew. Chem. Int. Ed., 2022, 61, e202208678.

2. Lu Miao, Wei Zhou, Chunyu Yan, Yuebin Zhang, Qinglong Qiao, Xuelian Zhou, Yingzhu Chen, Guangying Wang, Zhendong Guo, Jun Liu, Hailong Piao, Xia Pan, Mengxue Yan, Weijie Zhao, Guohui Li*, Yueqing Li*, Zhaochao Xu*, Rapid Screening of SARS-CoV-2 Inhibitors via Ratiometric Fluorescence of RBD- ACE2 Complexes in Living Cells by Competitive Binding, Acta. Pharm. Sin. B, 2022, 10.1016/j.apsb.2022.05.033.

3. Qinglong Qiao, Wenjuan Liu, Jie Chen, Xia Wu, Fei Deng, Xiangning Fang, Ning Xu, Wei Zhou, Shaowei Wu, Wenting Yin, Xiaogang Liu, Zhaochao Xu*. An Acid-regulated Self-blinking Fluorescent Probe for Resolving Whole-cell Lysosomes with Long-term Nanoscopy. Angew. Chem. Int. Ed., 2022, 61, e202202961.

4. Jie Chen, Chao Wang, Wenjuan Liu, Qinglong Qiao, Huan Qi, Wei Zhou, Ning Xu, Jin Li, Hailong Piao, Davin Tan, Xiaogang Liu and Zhaochao Xu*. Stable Super-Resolution Imaging Of Lipid Droplet Dynamics Through A Buffer Strategy With A Hydrogen-Bond Sensitive Fluorogenic Probe. Angew. Chem. Int. Ed., 2021, 60, 25104-25113.

5. Weijie Chi, # Qinglong Qiao, # Chao Wang, Jiazhu Zheng, Wei Zhou, Ning Xu, Xia Wu, Xiao Jiang, Davin Tan, Zhaochao Xu* and Xiaogang Liu*. Descriptor ΔG_C-O Enables The Quantitative Design Of Spontaneously Blinking Rhodamines For Live-Cell Super-Resolution Imaging. Angew. Chem. Int. Ed., 2020, 59, 20215-20223.

6. Chao Wang#, Qinglong Qiao#, Weijie Chi, Jie Chen, Wenjuan Liu, Davin Tan, Scott McKechnie, Da Lyu, Xiaofang Jiang, Wei Zhou, Ning Xu, Qisheng Zhang, Zhaochao Xu* and Xiaogang Liu*. Quantitative Design of Bright Fluorophores and AIEgens via the Accurate Prediction of Twisted Intramolecular Charge Transfer (TICT). Angew. Chem. Int. Ed., 2020, 59, 10160-10172.

7. Weijie Chi#, Jie Chen#, Wenjuan Liu#, Chao Wang, Qingkai Qi, Qinglong Qiao, Tee Meng Tan, Kangming Xiong, Xiao Liu, Keegan Kang, Young-Tae Chang*, Zhaochao Xu*, Xiaogang Liu*. A General Descriptor ΔE Enables the Quantitative Development of Luminescent Materials Based on Photoinduced Electron Transfer. J. Am. Chem. Soc., 2020, 142, 6777-6785.

8. Qingkai Qi, Weijie Chi, Yuanyuan Li, Qinglong Qiao, Jie Chen, Lu Miao, Yi Zhang, Jin Li, Wei Ji, Tao Xu*, Xiaogang Liu*, Juyoung Yoon*, Zhaochao Xu*. A H-Bond Strategy to Develop Acid-Resistant Photoswitchable Rhodamine Spirolactams for Super-Resolution Single-Molecule Localization Microscopy. Chem. Sci., 2019, 10, 4914-4922.

9. Weijie Chi#, Qinglong Qiao#, Richmond Lee, Wenjuan Liu, Yock Siong Teo, Danning Gu, Matthew J. Lang, Young-Tae Chang*, Zhaochao Xu*, Xiaogang Liu*, Photoexcitation Induced Twisted Intramolecular Charge Shuttle (TICS), Angew. Chem. Int. Ed., 2019, 58, 7073-7077

10. Xiaogang Liu#*, Qinglong Qiao#, Wenming Tian, Wenjuan Liu, Jie Chen, Matthew J. Lang and Zhaochao Xu*, Aziridinyl Fluorophores Demonstrate Bright Fluorescence and Superior Photostability by Effectively Inhibiting Twisted Intramolecular Charge Transfer, J. Am. Chem. Soc., 2016, 138, 6960- 6963.

11. Zhaochao Xu*, Kyung-Hwa Baek, Ha Na Kim, Jingnan Cui, Xuhong Qian, David R. Spring, Injae Shin*, Juyoung Yoon*, Zn²⁺–Triggered Amide Tautomerization Produces a Highly Zn²⁺–Selective, Cell–Permeable and Ratiometric Fluorescent Sensor, J. Am. Chem. Soc., 2010, 132, 601-610.

12. Zhaochao Xu, N. Jiten Singh, Jeesun Lim, Jie Pan, Ha Na Kim, Sungsu Park, Kwang S. Kim*, Juyoung Yoon*. Unique Sandwich Stacking of Pyrene-Adenine-Pyrenefor Selective and Ratiometric Fluorescent Sensing of ATP at Physiological pH. J. Am. Chem. Soc., 2009, 131, 15528-15533.

主页

徐兆超 研究员;杰青;优青

徐兆超研究员;杰青;优青