(1) Cutting-edge instruments and methods on extreme ultraviolet free electron laser- biomolecule mass spectrometry.
(2) Protein in-situ chemical labeling and interfacial structure characterization.
(3) The application of new structural mass spectrometry methods in protein structure-function relationship exploration, structural proteomics, drug development, etc.
(1) Member of the Mass Spectrometry Analysis Committee of the Chinese Chemical Society
(2) Member of the Chromatography Committee of the Chinese Chemical Society
(3) Member of Chinese Proteomics Committee
(4) UCAS-Springer Excellent Doctorate Theses Award
(5) Excellent Doctoral Dissertation CAS
[1] Zheyi Liu, Shirui Yang, Lingqiang Zhou, Min He, Yu Bai, Shan Zhao, Fangjun Wang*, Structural Characterization of Protein-Material Interfacial Interactions Using Lysine Reactivity Profiling-Mass Spectrometry. Nature Protocols, 2023, Doi: 10.1038/s41596-023-00849-0
[2] Yu Bai, Zheyi Liu, Yuanqing Li, Heng Zhao, Can Lai, Shan Zhao, Kaixian Chen, Cheng Luo*, Xueming Yang, Fangjun Wang*, Structural Mass Spectrometry Probes the Inhibitor-Induced Allosteric Activation of CDK12/CDK13-Cyclin K Dissociation., Journal of the American Chemical Society, 2023, 145, 21, 11477-11481
[3] Lingqiang Zhou, Zheyi Liu, Yongjie Guo, Shiwen Liu, Heng Zhao, Shan Zhao, Chunlei Xiao, Shun Feng*, Xueming Yang, Fangjun Wang*, Ultraviolet Photodissociation Reveals the Molecular Mechanism of Crown Ether Microsolvation Effect on the Gas-Phase Native-like Protein Structure., Journal of the American Chemical Society, 2023, 145, 2, 1285-1291
[4] Ye Zhou, Zheyi Liu, Mingdong Yao, Jun Chen, Yanan Xiao, Guangye Han, Jian-Ren Shen, Fangjun Wang*, Elucidating the Molecular Mechanism of Dynamic Photodamage of Photosystem II Membrane-protein Complex by Integrated Proteomics Strategy. CCS Chemistry, 2022, 4, 182-193
[5] Zheyi Liu, Wenxiang Zhang, Binwen Sun, Yaolu Ma, Min He, Yuanjiang Pan, Fangjun Wang*, Probing Conformational Hotspots for the Recognition and Intervention of Protein Complexes by Lysine Reactivity Profiling. Chemical Science, 2021, 12, 1451-1457
