报告时间：2023年5月31日（星期三）上午10:00

　　报告地点：能源学院M1-3会议室

　　报告人：南昌大学 万昊 教授

　　报告人简介:

　　万昊，南昌大学食品科学与资源挖掘全国重点实验室教授，食品学院教授，博士生和硕士生导师；担任国际著名SCI学术期刊审稿人，包括Analytical Chemistry、ACS Applied Materials& Interface、Theranostics、Carbon、Analytica Chimica Acta等；在食品科学、分析科学、生命科学、材料化学等领域开展了前沿性的基础交叉研究，并注重将科学研究与改善人体健康密切关联；其研究方向主要集中在以下几个方面：食品功能因子的稳态化及其精准递送、食品蛋白质组学、功能化纳米颗粒的构建及其在癌症精准治疗中的应用、生物仿生载体的构建及其在疾病治疗中的应用；主持国家自然科学青年基金、江西省杰出青年基金和江西省国家级高层次人才创新创业基金。截至目前为止，万昊以第一作者和共同第一作者或通讯作者身份在高水平期刊上发表19篇学术论文，包括Nature Methods、Nature Communications、PNAS、Advanced Materials、Advanced Functional Materials和Food Chemistry等；以共同作者身份参与发表20篇学术论文，包括Nature Medicine、Nature Biotechnology、Nano Today、Chemical Science等。论文总引用4247次。申请和授权专利7项，其中包括3件国外专利。所开发的高磁响应微球作为复杂生物样本前处理原料，已成功进行产业转化，实现了较好的市场销售。

　　报告摘要：

　　IBD mainly include Crohn's disease (CD) and ulcerative colitis (UC) and have aroused broad interests around word. Clinically, IBD patients always present recurrent abdominal pain, diarrhea, hematochezia, etc. With the progress in the study of probiotic, multiple studies have shown that gut modulation by probiotics plays a crucial part to fight IBD. Probiotics are a class of microorganisms that can bring benefits to the host, with the characteristics of regulating blood glucose metabolism, maintaining gut microbiota balance, improving lactose intolerance, enhancing immune functions, and so on. Despite aforementioned advances, probiotics usually demonstrate poor stability, high sensitivity to gastrointestinal environmental stresses during oral administration, resulting in inferior therapeutic outcome. What’s more, the low bacterial colonization efficacy, due to the inferior adhesion of probiotics to the intestinal wall, would further compromise the therapeutic effect. Hence, maintaining a high survival rate with high-efficiency intestinal colonization is essential for probiotics to exert effective functions to the host. Although various methods have been developed in the last few years to pursue a high survival rate with high-efficiency intestinal colonization for probiotics, these methods have exposed design limitations, tedious workflows or mechanical damage to probiotics. Hence, mantaing maintaining probiotic activity under complex gastrointestinal conditionsit still remains a challenge. It is urgent to develop a simple yet effective way to enhance the resistance ability of gastrointestinal environmental stresses as well as prolong intestinal retention for probiotics to better demonstrate their functions in vivo. Herein, we developed a modified-prebiotic “shiled” to improve the survival rate and retention of prebiotics in the gut so as to achieve the synergistic treatment effect in DSS-induced colitis mice. In our study, the modified prebiotic armed EcN demonstrated significantly enhanced resistance ability.

　　报告联系人：1822组 刘哲益

　　联系电话：0411-39787229