中国科学院大连化学物理研究所

简历介绍

周雍进，男，博士，研究员，博士生导师。2006年毕业于江南大学，获工学学士学位；2008年毕业于天津大学，获生物化工硕士学位；2012年毕业于中国科学院大连化学物理研究所，获得生物化工专业博士学位。2016年于瑞典查尔姆斯理工大学完成博士后研究；2017年引进入所工作至今，2018年晋升为研究员。目前担任合成生物制造研究中心主任。研究方向：（1）甲醇生物转化；（2）合成生物学工具开发；（3）天然产物生物合成。在Cell、Nature Energy、Nat. Metab.、Nat. Chem. Biol.、Nat. Commun.、PNAS、JACS等学术期刊上发表论文100余篇，申请发明专利36项，授权8项。

研究方向

　　主要研究方向是微生物合成生物学和代谢工程。

主要研究兴趣为：1）甲醇等一碳资源生物转化；2）微生物细胞反应器构建及优化；3）天然产物生物合成。详情请见课题组主页。

职务

社会任职

获奖及荣誉

代表论著

1. Damian L Ludig^#, Xiaoxin Zhai^#, Alexander Rittner, Christian Gusenda, Maximilian Heinz, Svenja Berlage, Ning Gao, Adrian J Jervis, Yongjin J Zhou*, Martin Grininger*, Engineering metazoan fatty acid synthase to control chain length applied in yeast, Nat. Chem. Biol., 2026, 22: 1078-1086

2. Zulin Wu^#, Jiaoqi Gao^#, Ning Gao, Yunxian Zhao, Yongjin J Zhou*, Engineering chronological lifespan toward a robust yeast cell factory, Proc. Natl. Acad. Sci. USA, 2025, 122(46): e2515324122

3. Ruibing Chen, Xianghui Chen, Yu Chen, Jindong Yang, Wansheng Chen*, Yongjin J Zhou*, Lei Zhang*, De novo biosynthesis of plant lignans by synthetic yeast consortia, Nat. Chem. Biol., 2025, 21: 1487-1496 (Cover story)

4. Wei Yu^#, Chenyue Zhang^#, Yunxia Li, Qing-An Chen, Qiang Fei*, Jiaoqi Gao*, Yongjin J Zhou*, Methanol biotransformation for the production of biodegradable plastic monomer L-lactate in yeast, Nat. Commun., 2025, 16: 10756

5. Jiaoqi Gao^#, Wei Yu^#, Yunxia Li, Mingjie Jin, Lun Yao, Yongjin J Zhou*, Engineering co-utilization of glucose and xylose for chemical overproduction from lignocellulose, Nat. Chem. Biol., 2023, 19: 1524-1531 (Cover story)

6. Xiaoxin Zhai, Jiaoqi Gao, Yunxia Li, Martin Grininger, Yongjin J Zhou*, Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast, Proc. Natl. Acad. Sci. USA, 2023, 120(12): e2220816120

7. Jiaoqi Gao, Yunxia Li, Wei Yu, Yongjin J Zhou*, Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol, Nat. Metab., 2022, 4: 932-943

8. Ruibing Chen, Jiaoqi Gao, Wei Yu, Xianghui Chen, Xiaoxin Zhai, Yu Chen, Lei Zhang*, Yongjin J Zhou*, Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast, Nat. Chem. Biol., 2022, 18: 520-529

9. Peng Cai, Xiaoyan Wu, Jun Deng, Linhui Gao, Yiwei Shen, Lun Yao, Yongjin J Zhou*, Methanol biotransformation toward high-level production of fatty acid derivatives by engineering the industrial yeast Pichia pastoris, Proc. Natl. Acad. Sci. USA, 2022, 119(29): e2201711119

10. Yongjin J Zhou, Eduard J Kerkhoven, Jens Nielsen*, Barriers and opportunities in bio-based production of hydrocarbons, Nat. Energy, 2018, 3: 925-935

主页

周雍进 研究员;杰青;优青

周雍进研究员;杰青;优青